V ABL ONCOGENES Meaning and
Definition
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V-abl oncogenes refer to a group of viral oncogenes that are derived from the Abelson murine leukemia virus (A-MuLV). These oncogenes are frequently used in molecular research to study the mechanisms of cell growth regulation and tumorigenesis.
The V-abl oncogenes encode a constitutively activated form of the Abelson tyrosine kinase, which plays a crucial role in cell signal transduction. When these oncogenes are introduced into normal cells, they can lead to uncontrolled cell growth and the formation of tumors. This property highlights their oncogenic potential.
The Abelson tyrosine kinase normally functions as a regulator of cell division and differentiation but when it becomes persistently activated due to the presence of V-abl oncogenes, it can disrupt the normal balance between cell proliferation and cell death. This dysregulation can lead to the abnormal growth and division of cells, causing the development of various types of tumors in different tissues.
Studies on V-abl oncogenes have provided key insights into the molecular mechanisms underlying oncogenesis and have greatly contributed to our understanding of cancer biology. These oncogenes have been widely used in experimental models to investigate the effects of aberrant tyrosine kinase activity and to develop targeted therapies for cancers caused by similar dysregulation of signaling pathways.
Common Misspellings for V ABL ONCOGENES
